Patent · US Active

Quantification of misfolded TNFR2:Fc

US9598718B2 · kind B2 · utility

2Cited by

3References

20Claims

0Family size

Assignee

Sandoz AG · CH

Inventors

Alfred Rupprechter · Kundl, AT
Michael Fuchs · Boise, US
Johann Holzmann · Kundl, AT
William Lamanna · Kundl, AT
Christoph Posch · Kundl, AT
Hansjorg Toll · Kundl, AT
Robert Mayer · Kundl, AT

Key dates

Filing date	Aug 8, 2014
Grant date	Mar 21, 2017
Priority date	—
Expiry date	Jan 31, 2035

Classification

Technology area (CPC G)Physics
CPC primaryG01N2440/20
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The present invention is directed to methods for determining the relative amount of wrongly disulphide bridged TNFR2:Fc in a sample of TNFR2:Fc, a fusion protein which is used in a variety of therapeutic applications. In addition, the invention pertains to a method for purifying TNFR2:Fc using said method for determining the percentage of wrongly disulphide bridged TNFR2:Fc, and to TNFR2:Fc compositions obtained thereby.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.