Protective solutions for organs

US9603354B2 · kind B2 · utility

Assignee

• DR. FRANZ KOEHLER CHEMIE GMBH · DE

Inventors

• Herbert de Groot · Goldkronach, DE
• Ursula Rauen · Essen, DE
• Gernot Koehler · Ludwigshafen, DE
• Wilfried Bruns · Biblis, DE

Key dates

• Filing date: Jun 2, 2011
• Grant date: Mar 28, 2017
• Expiry date: Jun 2, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described is a protective solution for avoiding ischemic, storage or ischemia/reperfusion to organs, or to isolated cell systems, or to tissue components after perfusion, surgery, transplantation, or cryopreservation and subsequent reperfusion, which contains alkali ions, and if need be also alkaline earth ions as the electrolyte, a buffer e.g. on a histidine derivation basis, as well as a polyol and/or a saccharide, has an osmolarity of about 290 mosm/l to about 350 mosm/l, as well as a pH value of about 6.8 to about 7.4, and to which hydroxamic acid, and/or one or more hydroxamic acid derivatives are added.