Pyrrolidine-2, 5-dione derivatives, pharmaceutical compositions and methods for use as IDO1 inhibitors

US9603836B2 · kind B2 · utility

Assignee

• iTeos Therapeutics SA · BE

Inventors

• Stefano Crosignani · Nivelles, BE
• Sandra Cauwenberghs · Halle, BE
• Gregory Driessens · Ottignies, BE
• Frederik Deroose · Gentbrugge, BE

Key dates

• Filing date: May 14, 2015
• Grant date: Mar 28, 2017
• Expiry date: May 14, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compound of Formula Ior pharmaceutically acceptable enantiomers, salts, solvates or prodrugs thereof. The invention further relates to the use of the compounds of Formula I as IDO1 inhibitors. The invention also relates to the use of the compounds of Formula I for the treatment and/or prevention of cancer and endometriosis. The invention also relates to a process for manufacturing compounds of Formula I.