Probiotic and prebiotic compositions, and methods of use thereof for treatment and prevention of graft versus host disease

US9603878B2 · kind B2 · utility

Assignee

• Evelo Biosciences, Inc. · US

Inventors

• David Arthur Berry · Brookline, US
• Shaila Rahman · Cambridge, US
• Johanne Kaplan · Framingham, US
• Neal Gordon · Lexington, US

Key dates

• Filing date: Dec 14, 2015
• Grant date: Mar 28, 2017
• Expiry date: Dec 14, 2035

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Probiotic compositions containing non-pathogenic microbial entities, e.g., bacterial or fungal entities, are described herein. The probiotic compositions may optionally contain or be used in conjunction with one or more prebiotics. Uses of the probiotic compositions to treat or prevent transplant disorders, e.g., graft-versus-host disease (GVHD), in a subject are also provided.