Diether based biodegradable cationic lipids for siRNA delivery
US9604908B2 · kind B2 · utility
32Cited by
2References
6Claims
0Family size
Assignee
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Key dates
| Filing date | Sep 19, 2016 |
| Grant date | Mar 28, 2017 |
| Priority date | — |
| Expiry date | Sep 19, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein are novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. The cationic lipids can demonstrate enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain coupled with inclusion of hydrolysable functionality in the lipid chains to enhance the efficiency and tolerability of in vivo delivery of siRNA.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.