Compounds as modulator of JAK-STAT pathway, methods and applications thereof

US9604974B2 · kind B2 · utility

Assignees

• UNIVERSITY OF MYSORE · IN
• NATIONAL UNIVERSITY OF SINGAPORE · SG
• BANGALORE UNIVERSITY · IN
• Cambridge Enterprise Limited · GB

Inventors

• Kanchugarakoppal Subbegowda Rangappa · Mumbai, IN
• Feng Basappa · Bengaluru, IN
• Chakrabhavi Dhananjaya Mohan · Mumbai, IN
• Shobith Rangappa · Mumbai, IN
• Hanumantharayappa Bharathkumar · Bengaluru, IN
• Gautam Sethi · Singapore, SG
• Andreas Bender · Cambridge, GB
• Peter Edward Lobie · Singapore, SG
• Kam Man Hui · Singapore, SG
• Alan Prem Kumar · Singapore, SG
• Vijay Kumar Pandey · Singapore, SG
• Julian FUCHS · Wien, AT
• Muthu Kumaraswamy Shanmugam · Singapore, SG
• Krishna Bulusu · Cambridge, GB
• Xiaoyun Dai · Singapore, SG
• Feng Li · Winchester, US
• Amudha Deivasigamani · Singapore, SG

Key dates

• Filing date: Jan 22, 2016
• Grant date: Mar 28, 2017
• Expiry date: Jan 22, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D265/16
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure relates to compound of structural Formula I and a method for preparing said compounds. The disclosure further relates to a method of employing the Formula I compounds for modulation of Janus kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway in cancer cells, and the corresponding use of compound of Formula I as anti-cancer agents.