Polyene compound, method for preparing the same, and antifungal drug comprising novel polyene compound as active ingredient
US9605015B2 · kind B2 · utility
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4Claims
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Key dates
| Filing date | Aug 31, 2012 |
| Grant date | Mar 28, 2017 |
| Priority date | — |
| Expiry date | Aug 31, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P19/62
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a novel polyene compound similar to nystatin, a method for preparing the same, and an antifungal drug comprising the novel polyene compound as an active ingredient. Compared to nystatin comprising one sugar, NNP, which is the polyene compound similar to nystatin, displays 300 times higher solubility and ten times lower cytotoxicity while maintaining antifungal activity, and thus can be useful in developing a novel polyene antifungal agent having improved solubility and less toxicity in terms of pharmacokinetics.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.