Antibacterial agents: salinamide derivatives

US9605028B2 · kind B2 · utility

Assignee

• Rutgers, the State University of New Jersey · US

Inventors

• Richard H. Ebright · New Brunswick, US
• Yon W. Ebright · New Brunswick, US
• Yu Feng · Cliffside Park, US
• David Degen · New Brunswick, US

Key dates

• Filing date: Dec 17, 2015
• Grant date: Mar 28, 2017
• Expiry date: Dec 17, 2035

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides compounds of formula (I):and salts thereof, wherein X and Y have any of the values defined herein. The compounds inhibit bacterial RNA polymerase, inhibit bacterial growth, and have applications in, analysis of RNA polymerase structure and function, control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, antibacterial therapy, and drug discovery.