Alteration of neuronal gene expression by synthetic piRNAs and by alteration of piRNA function

US9605260B2 · kind B2 · utility

Assignee

• IBIS BIOSCIENCES, INC. · US

Inventors

• David J. Ecker · Encinitas, US
• Todd P. Michael · Carlsbad, US
• Lendell L. Cummins · San Diego, US
• Mark W. Eshoo · Carlsbad, US
• Stanley Motley · Carlsbad, US
• Danny M. Chou · Carlsbad, US

Key dates

• Filing date: Mar 14, 2014
• Grant date: Mar 28, 2017
• Expiry date: Mar 14, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/154
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Provided herein are compositions and methods for the alteration of neuronal methylation by synthetic piRNAs or by alteration of piRNA function. Such alterations find use in the regulation and control of neural gene expression and concomitant neural functions. Further provided herein are systems and methods for the identification of target sites for regulation by piRNAs.