Stabilized glucagon solutions
US9610329B2 · kind B2 · utility
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2References
23Claims
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Key dates
| Filing date | Sep 27, 2010 |
| Grant date | Apr 4, 2017 |
| Priority date | — |
| Expiry date | Feb 2, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P3/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A formulation composed of a sugar such as glucose and a surfactant such as myristoyl lysophosphocholine (LMPC) has been designed to stabilize both hydrophilic and hydrophobic portions of the glucagon molecule, under prolonged physiological conditions, in a formulation that is sufficiently similar to the pH and osmolarity of plasma so as not to induce or to minimize site irritation. The combination of a simple sugar and an surfactant stabilizes the glucagon molecule in an aqueous solution for seven days at 37° C.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.