Process for the preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine

US9611247B2 · kind B2 · utility

Assignee

• DOW AGROSCIENCES LLC · US

Inventors

• Qiang Yang · Ellicott City, US
• Beth Lorsbach · Indianapolis, US
• Xiaoyong Li · Midland, US
• Gary Roth · Midland, US
• David E. Podhorez · Midland, US

Key dates

• Filing date: Sep 9, 2015
• Grant date: Apr 4, 2017
• Expiry date: Sep 9, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

3-(3-Chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine-·dihydrochloride with acrylonitrile to provide 1-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-3-amine, by oxidizing to provide 3-(3-amino-1H-pyrazol-1-yl)pyridine, and by converting the amino group to a chloro group by a Sandmeyer reaction.