Compositions and methods for inhibition of the JAK pathway

US9611260B2 · kind B2 · utility

Assignee

• Rigel Pharmaceuticals, Inc. · US

Inventors

• Hui Li · Santa Clara, US
• Thilo J. Heckrodt · San Francisco, US
• Yan Chen · Sunnyvale, US
• Darren McMurtrie · Daly City, US
• Vanessa Taylor · San Francisco, US
• Rajinder Singh · Belmont, US
• Pingyu Ding · Foster City, US
• Rose Yen · San Francisco, US

Key dates

• Filing date: May 29, 2015
• Grant date: Apr 4, 2017
• Expiry date: May 29, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/05
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK 2 and JAK3, are therapeutically useful. Also disclosed are methods of making the compounds.