Anti-plasmodium parasite antibodies

US9611318B2 · kind B2 · utility

Assignee

• Fraunhofer-Gesellschaft zur förderung der angewandten Forschung e.V. · DE

Inventors

• Rolf Fendel · Aachen, DE
• Torsten Klockenbring · Aachen, DE
• Stefan Barth · Jena, DE
• Stephanie Kapelski · Ekeren, BE
• Dominika Maskus · Aachen, DE
• Rainer Fischer · Monschau, DE
• Andreas Reimann · Krefeld, DE

Key dates

• Filing date: Jul 31, 2013
• Grant date: Apr 4, 2017
• Expiry date: Jul 31, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The technology provided herein relates to novel human antibodies against Plasmodium parasites, in particular against the malaria parasite Plasmodium falciparum. The present disclosure pertains to antibodies against merozoite surface protein 10 (MSP10). These antibodies have high affinity e.g. to Plasmodium falciparum schizonts and merozoites, inhibit the reinvasion of merozoites into erythrocytes and thereby neutralize parasitic multiplication.