Complex miRNA sets as novel biomarkers for an acute coronary syndrome

US9611511B2 · kind B2 · utility

Assignee

• Comprehensive Biomarker Center GmbH · DE

Inventors

• Andreas Keller · Ettlingen, DE
• Peer Stahler · Mannheim, DE
• Markus Beier · Heidelberg, DE
• Benjamin Meder · Dossenheim, DE
• Hugo Katus · Heidelberg, DE
• Wolfgang Rottbauer · Ulm, DE

Key dates

• Filing date: Apr 19, 2011
• Grant date: Apr 4, 2017
• Expiry date: Apr 19, 2031

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A90/10
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention relates to single polynucleotides or sets of polynucleotides for detecting single miRNAs or sets of miRNAs for diagnosing and/or prognosing of an acute coronary syndrome in a blood sample from a human. Further, the present invention relates to means for diagnosing and/or prognosing of an acute coronary syndrome comprising said polynucleotides or sets of polynucleotides. Furthermore, the present invention relates to a method for diagnosing and/or prognosing of an acute coronary syndrome based on the determination of expression profiles of single miRNAs or sets of miRNAs representative for an acute coronary syndrome compared to a reference. In addition, the present invention relates to a kit for diagnosing and/or prognosing of an acute coronary syndrome comprising means for determining expression profiles of single miRNAs or sets of miRNAs representative for an acute coronary syndrome and at least one reference.