Method of treating and preventing brain impairment using Na+-K+-2Cl-cotransporter isoform 1 inhibitors
US9616075B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Mar 15, 2013 |
| Grant date | Apr 11, 2017 |
| Priority date | — |
| Expiry date | Jun 2, 2033 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The disclosure relates to a method of treating and/or preventing brain impairment in a subject that has or is susceptible to ammonia neurotoxicity (increased plasma ammonia), by administering a Na-; —K+-2CI- cotransporter isoform 1 (“NKCC1”) inhibitor to the selected subject under conditions effective to treat and/or prevent brain impairment. The disclosure further relates to methods of maintaining the fundamental function of astrocytic potassium buffering and inhibiting accumulation of potassium star rounding astrocytes, both of which involve contacting astrocytes with a NKCC 1 inhibitor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.