Insulin vitamin D conjugates

US9616109B2 · kind B2 · utility

Assignee

• Extend Biosciences, Inc. · US

Inventors

• Tarik Soliman · Chester Springs, US
• Laura M. Hales · Cambridge, US
• Daniel B. Hall · Easton, US
• Howard Sard · Arlington, US
• Vishnumurthy Hegde · Chelmsford, US

Key dates

• Filing date: Oct 21, 2015
• Grant date: Apr 11, 2017
• Expiry date: Oct 21, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/62
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides non-hormonal vitamin D conjugated to insulin peptides that result in the peptides having increased absorption, bioavailability or circulating half-life when compared to non-conjugated forms. The vitamin D targeting groups are coupled to the insulin peptides via the third carbon on the vitamin D backbone.