Patent · US Active

Detoxified endotoxin immunogenic compositions and uses thereof

US9616116B2 · kind B2 · utility

1Cited by

2References

5Claims

0Family size

Assignees

UNIVERSITY OF MARYLAND, BALTIMORE · US
THE MEMORIAL HOSPITAL OF RHODE ISLAND · US
United States Army · US

Inventors

Alan Cross · Chevy Chase Section Five, US
Apurba Bhattacharjee · Kensington, US
Wendell D. Zollinger · Silver Spring, US
Steven M. Opal · Central Falls, US

Key dates

Filing date	Mar 3, 2015
Grant date	Apr 11, 2017
Priority date	—
Expiry date	Mar 3, 2035

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A50/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides an immunogenic composition of a lipopolysaccharide vaccine and a non-alum adjuvant. The immunogenic composition may be detoxified J5 core lipopolysaccharide of Escherichia coli non-covalently complexed with group B meningococcal outermembrane protein. Also provided are methods for preventing an infection caused by a Gram-negative bacteria in an individual via administering the immunogenic compositions to the individual.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.