Pharmaceutically acceptable solubilizing composition and pharmaceutical dosage form containing same

US9616130B2 · kind B2 · utility

Assignee

• Abb Vie Deutschland Gmbh & Co. KG · DE

Inventors

• Jörg Rosenberg · Ellerstadt, DE
• Jorg Breitenbach · Mannheim, DE
• Kennan C. Marsh · Lake Forest, US
• Bernd Liepold · Dossenheim, DE
• Christoph Schmidt · Kriftel, DE
• Ute Lander · Dannenfels, DE

Key dates

• Filing date: Jul 14, 2015
• Grant date: Apr 11, 2017
• Expiry date: Jul 14, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/2027
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pharmaceutically acceptable solubilizing compositions comprising (i) at least one tocopheryl compound having a polyalkylene glycol moiety and (ii) at least one alkylene glycol fatty acid monoester or mixture of alkylene glycol fatty acid mono-and diester are disclosed. The solubilizing compositions are useful in the manufacture of pharmaceutical dosage forms comprising a melt-processed mixture of at least one active ingredient and at least one pharmaceutically acceptable polymer. The solubilizing compositions enhance the bioavailability of the active ingredient following oral intake.