Tubular nanostructure targeted to cell membrane

US9617157B2 · kind B2 · utility

Assignee

• Deep Science, LLC · US

Inventors

• Mahalaxmi Gita Bangera · Renton, US
• Ed Harlow · Boston, US
• Roderick A. Hyde · Redmond, US
• Muriel Y. Ishikawa · Livermore, US
• Edward K.Y. Jung · Bellevue, US
• Eric C. Leuthardt · Chesterfield, US
• Nathan P. Myhrvold · Bellevue, US
• Dennis J. Rivet · Chesapeake, US
• Elizabeth A. Sweeney · Seattle, US
• Clarence T. Tegreene · Bellevue, US
• Lowell L. Wood, JR. · Bellevue, US
• Victoria Y.H. Wood · Livermore, US

Key dates

• Filing date: Jan 30, 2009
• Grant date: Apr 11, 2017
• Expiry date: May 9, 2035

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/915
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Devices, compositions, and methods are described which provide a tubular nanostructure or a composite tubular nanostructure targeted to a lipid bilayer membrane. The tubular nanostructure includes a hydrophobic surface region flanked by two hydrophilic surface regions. The tubular nanostructure is configured to interact with a lipid bilayer membrane and form a pore in the lipid bilayer membrane. The tubular nanostructure may be targeted by including at least one ligand configured to bind to one or more cognates on the lipid bilayer membrane of a target cell.