Dipeptidyl peptidase-IV inhibitor

US9617300B2 · kind B2 · utility

Assignee

• Morinaga Milk Industry Co., Ltd. · JP

Inventors

• Akio Yamada · Yokohama, JP
• Takuma Sakurai · Yokohama, JP
• Daisuke Ochi · Munich, DE

Key dates

• Filing date: Feb 21, 2013
• Grant date: Apr 11, 2017
• Expiry date: Feb 21, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An excellent peptidyl peptidase-IV inhibitor and the like are provided. A peptide consisting of Val-Pro-X wherein X represents an amino acid residue (except for L-proline residue); the aforementioned X is preferably one selected from a basic amino acid residue, an aliphatic neutral amino acid residue, an amide group-carrying neutral amino acid residue, or an aromatic group-carrying neutral amino acid residue; the aforementioned X is preferably one selected from an alanine residue, a glutamine residue, a methionine residue, an asparagine residue, a glycine residue, a valine residue, a tyrosine residue, a serine residue, and a lysine residue; a dipeptidyl peptidase-IV inhibitor, a blood sugar rise suppressing agent, a vascular endothelial disorder suppressing agent, and an angiotensin converting enzyme inhibitor containing the aforementioned peptide as an active ingredient.