Method of imaging a cardiovascular disease with an anti-macrophage mannose receptor immunoglobulin single variable domain

US9617339B2 · kind B2 · utility

Assignees

• VIB VZW · BE
• VRIJE UNIVERSITEIT BRUSSEL · BE

Inventors

• Patrick De Baetselier · Berchem, BE
• Geert Raes · Sint-Genesius-Rode, BE
• Steve Schoonooghe · Kessel-Lo, BE
• Jens De Vos · Strombeek-Bever, BE
• Tony Lahoutte · Ganshoren, BE
• Nick Devoogdt · Zemst, BE
• Sophie Hernot · Machelen, BE
• Gezim Bala · Brussels, BE
• Simon Tierens · Londerzeel, BE

Key dates

• Filing date: Mar 17, 2014
• Grant date: Apr 11, 2017
• Expiry date: Mar 17, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure relates to the field of cardiovascular diseases. In particular, immunoglobulin single variable domains directed against macrophage mannose receptor (MMR) are provided that can be used in the diagnosis, prognosis and/or monitoring of cardiovascular diseases or as therapeutics. Also, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the disclosure are useful at different stages of cardiovascular diseases, including post-infarction cardiovascular events. Further, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the disclosure are particularly useful for the in vivo targeting and/or imaging of vulnerable atherosclerotic plaques.