Nucleic acids encoding vitamin K expoxide reductase subunit 1 and vitamin K dependent protein expression and methods of using same
US9617523B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | Jan 27, 2006 |
| Grant date | Apr 11, 2017 |
| Priority date | — |
| Expiry date | Jan 27, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y304/21022
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a host organism containing recombinant nucleic acids coding for the vitamin K reductase complex subunit 1 (VKORC1) and recombinant nucleic acids coding for a vitamin K dependent (VKD) protein, wherein both the recombinant VKORC1 and the recombinant VKD protein are expressed in said host organism. Further, the present invention relates to a cell culture system comprising cells which contain said recombinant nucleic acids and to methods for improving the productivity of recombinant VKD protein expression in a host organism being cultured in suitable systems.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.