Methods and compositions for determining resistance to androgen receptor therapy
US9617602B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 26, 2013 |
| Grant date | Apr 11, 2017 |
| Priority date | — |
| Expiry date | Jul 26, 2033 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/723
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described herein are modified androgen receptor polypeptides that are resistant to inhibition by an androgen receptor inhibitor. Described herein are compositions, combinations, and kits containing the modified androgen receptor polypeptides and methods of using the modified androgen receptor polypeptides. Also described herein are methods of using the modified androgen receptor polypeptides as screening agents for the identification and design of third-generation androgen receptor modulators. Also described herein are third-generation androgen receptor modulators that inhibit the activity of the modified androgen receptor polypeptides. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such androgen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions, including cancers, such as castration resistant prostate cancers, that are mediated or dependent upon androgen receptors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.