Sperm-specific cation channel, Catsper2, and uses therefor
US9618521B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Apr 10, 2014 |
| Grant date | Apr 11, 2017 |
| Priority date | — |
| Expiry date | Apr 10, 2034 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/852
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper2) are disclosed. The CatSper2 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper2 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper2 activity, methods of genotyping subjects with respect to CatSper2, methods of diagnosing and treating CatSper2-mediated disorders, including infertility, as well as methods of doing business related to CatSper2-mediated disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.