Patent · US Active

Contrast reagent leakage correction in dynamic susceptibility contrast magnetic resonance imaging

US9619875B2 · kind B2 · utility

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17Claims
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Key dates

Filing dateApr 23, 2015
Grant dateApr 11, 2017
Priority date—
Expiry dateApr 23, 2035

Classification

  • Technology area (CPC G)Physics
  • CPC primaryG16H30/40
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Disclosed are methods and systems for calculating a contrast reagent (CR) extravasation rate constant and generating a contrast reagent leakage corrected relative cerebral blood volume (rCBV) image map of a brain region from dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) time-course image data based on pharmacokinetic first principles. In one example approach, a computerized method may include performing a linearization transform of a DSC MRI time-course equation which accounts for an intravascular contribution and an extravasating component, and calculating CR leakage from a slope of a linear portion of the transformed data.

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