Bioerodible wraps and uses therefor

US9622849B2 · kind B2 · utility

Assignee

• University of Pittsburgh—Of the Commonwealth System of Higher Education · US

Inventors

• Mohammed S. El-Kurdi · Pittsburgh, US
• J. Christopher Flaherty · Winter Haven, US
• Yi Hong · Irving, US
• Jonathan McGrath · Middletown, US
• Lorenzo Soletti · Pittsburgh, US
• John J. Stankus · Campbell, US
• David A. Vorp · Pittsburgh, US
• William R. Wagner · Escondido, US

Key dates

• Filing date: Oct 28, 2010
• Grant date: Apr 18, 2017
• Expiry date: Sep 23, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61F2002/072
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. 5 Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.