Formation of stable submicron peptide or protein particles by thin film freezing

US9622974B2 · kind B2 · utility

Assignee

• The Board of Regents of the University of Texas · US

Inventors

• Keith P. Johnston · Austin, US
• Joshua Engstrom · Woodinville, US
• Robert O. WILLIAMS, III · Austin, US

Key dates

• Filing date: Jan 22, 2015
• Grant date: Apr 18, 2017
• Expiry date: Jan 22, 2035

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2982
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm−1 area/volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30° C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm−1.