Patent · US Active

Compositions and methods for preparing Staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions

US9623100B2 · kind B2 · utility

1Cited by

30References

36Claims

0Family size

Assignee

Wyeth, LLC · US

Inventors

Stephen John Freese · Cornwall-on-Hudson, US
Annaliesa Sybil Anderson · Upper Saddle River, US
Viliam Pavliak · Pittsford, US
Kathrin Ute Jansen · Doylestown, US
Ingrid Lea Scully · Patterson, US
Tracy Dee Scott · Foristell, US
Jasdeep Singh Nanra · Suffern, US
A. Krishna Prasad · Chapel Hill, US
Bruce A. Green · Pittsford, US

Key dates

Filing date	Jul 28, 2015
Grant date	Apr 18, 2017
Priority date	—
Expiry date	Jul 28, 2035

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K2039/64
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to immunogenic conjugates comprising S. aureus serotype 5 and 8 capsular polysaccharides conjugated to carrier proteins and methods for their preparation and use. Methods for making the immunogenic conjugates of the invention involve covalent conjugation of the capsular polysaccharides with the carrier proteins using conjugation chemistry involving either 1,1-carbonyl-di-1,2,4-triazole (CDT) or 3-(2-pyridyldithio)-propionyl hydrazide (PDPH).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.