Fused-bicyclic aryl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors

US9624175B2 · kind B2 · utility

Assignee

• FORMA Therapeutics, Inc. · US

Inventors

• Jian Lin · Watertown, US
• Anna Ericsson · Keyano, CA
• Ann-Marie Campbell · Monroe, US
• Gary Gustafson · Ridgefield, US
• Zhongguo Wang · Lexington, US
• R. Bruce Diebold · Waltham, US
• Susan Ashwell · Plainsboro, US
• David R. Lancia, Jr. · Boston, US
• Justin Andrew Caravella · Cambridge, US
• Wei Lu · Newton, US

Key dates

• Filing date: Sep 18, 2015
• Grant date: Apr 18, 2017
• Expiry date: Sep 18, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula:where A, B, U, V, Z, W1, W2, W3, and R1-R6 are described herein.