Substituted bipiperidinyl derivatives

US9624199B2 · kind B2 · utility

Assignee

• Bayer Pharma Aktiengesellschaft · DE

Inventors

• Eva Maria Becker-Pelster · Wuppertal, DE
• Philipp Buchgraber · Leverkusen, DE
• Anja Buchmüller · Essen, DE
• Karen Engel · Waldkraiburg, DE
• Andreas Göller · Wuppertal, DE
• Herbert Himmel · Essen, DE
• Raimund Kast · Wuppertal, DE
• Joerg Keldenich · Wuppertal, DE
• Carsten Schmeck · Wuppertal, DE
• Hanna Tinel · Wuppertal, DE
• Frank Wunder · Wuppertal, DE

Key dates

• Filing date: Dec 16, 2014
• Grant date: Apr 18, 2017
• Expiry date: Dec 16, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/107
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to novel substituted bipiperidinyl derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.