4H-thieno[3,2-C]chromene-based inhibitors of Notum Pectinacetylesterase and methods of their use

US9624238B2 · kind B2 · utility

Assignee

• LEXICON PHARMACEUTICALS, INC. · US

Inventors

• Joseph Barbosa · Lambertville, US
• Kenneth G. Carson · Princeton, US
• Michael Walter GARDYAN · Uniontown, US
• Jason Healy · Monmouth Junction, US
• Qiang Han · Plainsboro, US
• Ross Mabon · Lambertville, US
• Praveen PABBA · Pennington, US
• James E. Tarver · Levittown, US
• Kristen M. Terranova · Lawrenceville, US
• Ashok Tunoori · Princeton, US
• Xiaolian Xu · Princeton, US

Key dates

• Filing date: May 21, 2014
• Grant date: Apr 18, 2017
• Expiry date: May 21, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D333/52
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds that may be used to inhibit Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting bone.