Factor XII inhibitors for the treatment of silent brain ischemia and ischemia of other organs

US9624307B2 · kind B2 · utility

Assignees

• The General Hospital Corporation · US
• CSL Behring AG · DE

Inventors

• Matthias Nahrendorf · Boston, US
• Ralph Weissleder · Peabody, US
• Gerhard Dickneite · Marburg, DE
• Guido Stoll · Rimpar, DE
• Marc Nolte · Marburg, DE

Key dates

• Filing date: Mar 9, 2012
• Grant date: Apr 18, 2017
• Expiry date: Mar 9, 2032

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Silent brain ischemia (SBI) or ischemia of other organs can result from an embolism that is introduced into the arterial system during a medical procedure. The application provides a method of administering a FXII inhibitor in a patient receiving a medical procedure and animal models useful for studying ischemia including SBI and ischemia in other organs, and for evaluating candidate therapeutics.