Patent · US Active

Blood-brain barrier targeting antibodies

US9629801B2 · kind B2 · utility

1Cited by

2References

12Claims

0Family size

Assignee

Wisconsin Alumni Research Foundation · US

Inventors

Eric V. Shusta · Madison, US
Angela Richards Jones · Durham, US
Charles C. Stutz · Madison, US

Key dates

Filing date	Jan 9, 2015
Grant date	Apr 25, 2017
Priority date	—
Expiry date	Jan 9, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/77
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

This application discloses a BBB-selective antibody. The BBB-selective antibody comprises a protein encoded by a DNA sequence comprising SEQ ID NO:7 (CDRH1 of scFv 15), SEQ ID NO:8 (CDRH2 of scFv 15), SEQ ID NO:9 (CDRH3 of scFv 15), SEQ ID NO:10 (CDRL1 of scFv 15), SEQ ID NO:11 (CDRL2 of scFv 15) and SEQ ID NO:12 (CDRL3 of scFv 15) or a DNA sequence comprising SEQ ID NO:19 (CDRH1 of scFv 38), SEQ ID NO:20 (CDRH2 of scFv 38), SEQ ID NO:21 (CDRH3 of scFv 38), SEQ ID NO:22 (CDRL1 of scFv 38), SEQ ID NO:23 (CDRL2 of scFv 38) and SEQ ID NO:24 (CDRL3 of scFv 38). Preferably, the BBB-selective antibody comprises a protein encoded by SEQ ID NO:1 or 3.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.