Methods for synthesizing amatoxin building block and amatoxins

US9630907B2 · kind B2 · utility

Assignee

• Heidelberg Pharma GmbH · DE

Inventors

• Christian Lutz · Kassel, DE
• Christoph Mueller · Birkenau, DE
• Werner Simon · Seeheim-Jugenheim, DE

Key dates

• Filing date: Jul 12, 2013
• Grant date: Apr 25, 2017
• Expiry date: Jul 12, 2033

Classification

• Technology area (CPC —): General

Abstract

The invention relates to novel methods for synthesizing a synthon for γ,δ-dihydroxyisoleucine 1 (CAS No. 55399-94-5] as building block for the synthesis of amatoxins, and for novel methods for synthesizing amatoxins using such building block.