Biocatalyzed synthesis of the optically pure (R) and (S) 3-methyl-1,2,3,4-tetrahydroquinoline and their use as chiral synthons for the preparation of the antithrombic (21R)- and (21S)-argatroban
US9630923B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Jan 11, 2016 |
| Grant date | Apr 25, 2017 |
| Priority date | — |
| Expiry date | Jan 11, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P41/004
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to the biocatalyzed synthesis of enantiomerically pure (3R) and (3S)-methyl-1,2,3,4-tetrahydroquinoline. Said enantiomerically pure compounds are useful as chiral synthons in organic synthesis and, in particular, for the preparation of diastereomerically pure (21R) and (21S)-agratroban and its analogs. New compounds used as intermediates in the process of the invention are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.