Dipeptide analogs for treating conditions associated with amyloid fibril formation

US9630989B2 · kind B2 · utility

Assignee

• Ramot at Tel-Aviv University Ltd. · IL

Inventors

• Ehud Gazit · Ramat HaSharon, IL
• Yaniv Amir · Yehud Monosson, IL
• Ludmila Buzhansky · Modiin-Maccabim-Reut, IL
• Ulrich Abel · Schifferstadt, DE
• Anat Frydman-Marom · Nes Ziona, IL

Key dates

• Filing date: Jul 22, 2015
• Grant date: Apr 25, 2017
• Expiry date: Jul 22, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Dipeptide analogs comprising a tryptophan (Trp) moiety coupled to a beta-sheet breaker moiety derived from alpha-aminoisobutyric acid (Aib) are disclosed. The dipeptide analogs exhibit an improved performance in inhibiting amyloid fibril formation, as compared to previously described dipeptides. Compositions containing the dipetide analogs and uses thereof in treating amyloid-associated diseases and disorders are also disclosed.