PH-sensitive compositions for delivery of beta lapachone and methods of use
US9631041B2 · kind B2 · utility
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Key dates
| Filing date | Aug 11, 2011 |
| Grant date | Apr 25, 2017 |
| Priority date | — |
| Expiry date | Aug 25, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08F2438/01
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein are compounds comprising a polymer conjugated with a pH-sensitive prodrug of beta-lapachone, wherein the compound is capable of forming a micelle, and wherein the pH-sensitive prodrug comprises a pH-sensitive linker selected from the group consisting of: an aryl imine and an aliphatic imine. Also provided are micelles comprised of such polymer-prodrug conjugates. Further provided are methods for treating cancer with the micelles.
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