Tissue engineered model

US9631173B2 · kind B2 · utility

Assignee

• CPSI Holdings LLC · US

Inventors

• John G. Baust · Candor, US
• Joshua T. Smith · Hudson, US
• Kimberly L. Santucci · Apalachin, US
• Kristi K. Snyder · Candor, US
• Anthony T. Robilotto · Binghamton, US
• Robert G. Van Buskirk · Apalachin, US
• John M. Baust · Owego, US
• William L. Corwin · Johnson City, US
• Jennie F. McKain · Endicott, US

Key dates

• Filing date: Nov 6, 2015
• Grant date: Apr 25, 2017
• Expiry date: Nov 6, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2537/00
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A tissue engineered model (TEM) structure, an apparatus and method for making a TEM structure, and methods of using a TEM structure are disclosed. In an embodiment, the TEM structure includes at least one TEM segment. Each TEM segment includes a frame defining a bounded area, the frame having a height, a first edge, and a second edge opposite the first edge, each of the first edge and the second edge defining a perimeter of the bounded area, and the height defining a distance between the first edge and the second edge; a membrane affixed to the first edge about a perimeter of the frame; and a solidified gel and cell matrix disposed within the bounded area within the frame, wherein the solidified gel and cell matrix substantially fills a volume defined by the bounded area and the height of the frame.