Simulation-based estimation of elasticity parameters and use of same for non-invasive cancer detection and cancer staging
US9636075B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 6, 2013 |
| Grant date | May 2, 2017 |
| Priority date | — |
| Expiry date | Apr 17, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06T2219/2021
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Simulation-based estimation of elasticity parameters and use of same for non-invasive cancer detection and cancer staging are disclosed. According to one aspect, a method for simulation-based estimation of elasticity parameters includes constructing a 3D model of an object comprising biological tissue, the model having a first shape and an elasticity value. A simulation iteration is then performed, which includes simulating the application of an external force to the model, causing the model to have a second shape, measuring the difference between the second shape and a target shape, and determining whether the measured difference between the second shape and the target shape is within a threshold of error. If the measured difference is not within the threshold of error, the process performs additional iterations using adjusted elasticity or force values until the measured difference is within the threshold of error, at which time the final elasticity and force values are reported. In one embodiment, the elasticity value is mapped to a diagnostic parameter, such as an indication of the possibility, presence, or stage of cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.