Targeting multiple receptors on a cell surface for specific cell targeting
US9636419B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 13, 2014 |
| Grant date | May 2, 2017 |
| Priority date | — |
| Expiry date | Oct 13, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/6897
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of delivering a cargo agent into cytosol of a cell can include: providing the delivery system of one of the embodiments described herein having the first and second delivery platforms; and administering the delivery system to a cell so as to cause targeting of two features on the cell so as to: cause endocytosis of the first and second delivery platforms of the delivery system into a common endosome, destabilize the endosome of the cell having the delivery system, release the cargo agent from the second linker; and release the cargo agent from the destabilized endosome into cytosol of the cell. A method of treating a disease can include: performing the method of method of delivering a cargo agent into cytosol of a cell in a subject having a disease, wherein the cargo agent is a therapeutic agent for the disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.