Fluorine substituted cyclic amine compounds and preparation methods, pharmaceutical compositions, and uses thereof

US9637454B2 · kind B2 · utility

Assignee

• SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN

Inventors

• Hong Liu · Shanghai, CN
• Haiyan Zhang · Shanghai, CN
• Yu Zhou · Shanghai, CN
• Yan Fu · Shanghai, CN
• Hualiang Jiang · Shanghai, CN
• Xican Tang · Shanghai, CN
• Kaixian Chen · Shanghai, CN

Key dates

• Filing date: Oct 17, 2013
• Grant date: May 2, 2017
• Expiry date: Oct 17, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/107
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to the field of pharmaceutical chemistry and pharmacotherapeutics, and in particular to compounds of general formula I, racemates, R-isomers, S-isomers, and pharmaceutically acceptable salts thereof and their mixtures, and the preparation methods thereof and a pharmaceutical composition containing the compounds and uses thereof as an acetylcholine esterase inhibitor.