Sodium and calcium salts of dihydroquinazoline derivative and use thereof as antiviral agents

US9637459B2 · kind B2 · utility

Assignee

• AiCuris GmbH & Co. KG · DE

Inventors

• Alfons Grunenberg · Wuppertal, DE
• Mathias Berwe · Sprockhövel, DE
• Birgit Keil · Düsseldorf, DE
• Edwin Aret · Almere, NL
• Kerstin Paulus · Ratingen, DE
• Wilfried Schwab · Altentreptow, DE

Key dates

• Filing date: Feb 28, 2013
• Grant date: May 2, 2017
• Expiry date: Feb 28, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/84
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to sodium and calcium salts of {8-fluoro-2-[4-(3-methoxyphenyl)piperazine-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazoline-4-yl}acetic acid and solvates thereof, to the use thereof in a method of treatment and/or prophylaxis of virus infections and to the use thereof for producing drugs for use in methods of treatment and/or prophylaxis of diseases, more particularly the use thereof as antiviral agents, more particularly against cytomegaloviruses.