3′ Equatorial-fluorine-substituted neuraminidase inhibitor compounds, compositions and methods for the use thereof as anti-virals

US9637465B2 · kind B2 · utility

Assignee

• University of British Columbia · CA

Inventors

• Stephen Withers · Vancouver, CA
• Hongming Chen · Belmont, US
• Ricardo Resende · Vancouver, CA
• Jennifer Lois Breschkin · Melbourne, AU

Key dates

• Filing date: Jan 17, 2013
• Grant date: May 2, 2017
• Expiry date: Jan 17, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D309/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Equatorial 2,3-fluorinated glycosides compounds of formula (I) useful for the treatment or prophylaxis of viral infection, particularly viral influenza, the methods for their preparation, and their pharmaceutical compositions. The therapeutic effect is achieved via inhibition of viral neuraminidases.