Multi-component inhibitors of nucleic acid polymerases
US9637551B2 · kind B2 · utility
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17References
11Claims
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Key dates
| Filing date | Dec 11, 2009 |
| Grant date | May 2, 2017 |
| Priority date | — |
| Expiry date | Apr 28, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/76
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides multi-component inhibitors of nucleic acid polymerases, methods of making, and methods of using same. One component of the multi-component inhibitor is a molecule that binds to a polymerase (i.e., a polymerase-binding molecule (PBM)), but does not thereby substantially inhibit its polymerase activity. Another component is a molecule or complex of molecules that binds to a PBM (i.e., a PBM-binding molecule). The combination of the PBM and PBM-binding molecule/complex substantially inhibits polymerase activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.