Nano-sized particles comprising multi-headed amphiphiles for targeted drug delivery

US9642803B2 · kind B2 · utility

Assignee

• BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY · IL

Inventors

• Charles Linder · Rehovot, IL
• Sarina Grinberg · Meitar, IL
• Eliahu Heldman · Rehovot, IL

Key dates

• Filing date: May 4, 2010
• Grant date: May 9, 2017
• Expiry date: Apr 30, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C229/22
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Nano-sized particles are provided comprising at least one multi-headed amphiphilic compound, in which at least one headgroup of said multi-headed amphiphilic compound is selectively cleavable or contains a selectively cleavable group, and at least one biologically active agent, which is both encapsulated within the nano-particle and non-covalently associated thereto.