Methods for treating and preventing neutrophil-derived net toxicity and thrombosis
US9642822B2 · kind B2 · utility
15Cited by
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17Claims
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Assignee
Inventors
Key dates
| Filing date | May 25, 2012 |
| Grant date | May 9, 2017 |
| Priority date | — |
| Expiry date | Sep 25, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y301/21001
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Embodiments of the technology described herein are based upon the discoveries that neturophil extracellular traps (NETs) provide a stimulus for thrombus formation and that NETs are present in stored blood products. Accordingly, some embodiments relate to methods of treating and preventing toxicity of NETs and thrombosis caused by NETs. Additional embodiments are directed towards methods of treating stored blood products to prevent transfusion-related injuries.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.