Substance having tyrosine kinase inhibitory activity and preparation method and use thereof

US9642839B2 · kind B2 · utility

Assignee

• Institute of radiation medicine, academy of military medical sciences, PLA. · CN

Inventors

• Xiaoming Yang · San Diego, US
• Lin Wang · Qingdao, CN
• Changyan Li · Beijing, CN
• Yiqun Zhan · Beijing, CN
• Jing Liu · San Diego, US
• Teng Luo · Beijing, CN
• Haiyan Yan · Beijing, CN
• Shouguo Zhang · Beijing, CN
• Wei Li · Lexington, US
• Xiaoxue Wen · Beijing, CN
• Tao Peng · Kenmore, US
• Lu Li · Beijing, CN

Key dates

• Filing date: Jun 20, 2013
• Grant date: May 9, 2017
• Expiry date: Jun 20, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed in the present disclosure are substances having tyrosine kinase inhibitory activity and a preparation method and use thereof, wherein the substances are the compounds having the structure of general formula (I) or the geometric isomers or pharmaceutical salts thereof. Through evaluation on tyrosine kinase inhibitory activity and related experiments, the present disclosure demonstrates that these compounds have a good tyrosine kinase inhibitory activity, and may inhibit a variety of tumor cells, and thus may be developed into drugs for preventing and treating tumor diseases, especially liver cancer, lung cancer and neuroblastoma.