Combinations of TGFβ and COX-2 inhibitors and methods for their therapeutic application
US9642873B2 · kind B2 · utility
3Cited by
6References
37Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 4, 2011 |
| Grant date | May 9, 2017 |
| Priority date | — |
| Expiry date | Jul 16, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/31
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides compositions and methods for using combinations of TGFβ1 and Cox-2 inhibitors and TGFβ1 and Hoxb13 inhibitors for the treatment of various medical conditions, including skin scaring due to trauma wounds and surgery, corneal and retina scaring due to injury and surgery, internal organ scaring due to injury and surgery, heart tissue scaring due to heart attack and surgery, and lung, liver, and kidney fibrosis due to inflammation and injury. One example is to use siRNA inhibitors to silence TGFβ1 and Cox-2 at the same time, resulting in significant less scar formation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.