Compositions for rapidly treating severe hypoglycemia
US9642894B2 · kind B2 · utility
2Cited by
38References
2Claims
0Family size
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Inventor
Key dates
| Filing date | Apr 1, 2015 |
| Grant date | May 9, 2017 |
| Priority date | — |
| Expiry date | Apr 1, 2035 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P3/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is a composition for parenteral administration comprising a glucagon peptide which has been dried in a non-volatile glycine buffer, and wherein the glucagon peptide has a pH memory that is about equal to the pH of the glucagon peptide in the non-volatile buffer, wherein the pH memory is between 2.5 to 3.5, an aprotic polar solvent, wherein the peptide is solubilized in the aprotic polar solvent, and wherein the aprotic polar solvent is dimethyl sulfoxide (DMSO), trehalose, glycine, and optionally hydrochloric acid, wherein the moisture content of the composition is less than 5 wt. %.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.