Tubulin polymerization inhibitor and method for synthesizing same
US9643959B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Apr 22, 2014 |
| Grant date | May 9, 2017 |
| Priority date | — |
| Expiry date | Apr 22, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to (E)-ethyl 2-(2-methyl-3-((2-(naphtho[2,1-b]furan-2-carbonyl)hydrazono)methyl)-1H-indol-1-yl)acetate as a novel tubulin polymerization inhibitor and a method for synthesizing the same. The compound of the present invention can inhibit mitosis and induce apoptosis and thus be used as an anticancer agent, by binding to tubulin to inhibit microtube polymerization. According to the synthesis method of the present invention, the reaction is simplified and the efficiency is 60% or higher, leading to a very high yield, thereby providing an effective synthesis method.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.